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an autosampler for sample depositing and storage


lab sampling and sample preparation in bioprocess development are often done manually. therefore, deviations can occur, results are timely delayed, recorded manually and missing during weekends and nights. numera® is a modular system which provides an integrated and customized process analytical technology (pat) improvement. it enables on-line analytics for reliable results in real-time 24/7. combined with lucullus, the entire workflow of sampling design, systematic sampling automation, bioprocess monitoring, and feedback control is covered by an all-in-one solution.


reliability

accurate sample preparation leads to reliable data


flexibility

individually design sample processing and analysis


efficiency

gain knowledge in real-time for faster development

product features
  • low-volume and high-frequency sampling

    monitoring of multiple bioprocesses with high-frequency and fully automated sampling around the clock

  • precise sample preparation

    significant and reliable data with swiss precision technology

  • membrane filtration

    consistent cell removal and maximum sample yield with high cell densities

  • integration in lucullus pims

    from planning to evaluation: a unique solution from a single provider

specification

setups

standard setup

advanced setup

multiplexer modules

max 3

max 4

reactors

max 12

max 16

sample path

predefined sample path for each sample

individual sample path for each sample in one process

analyzer

1 hplc and 1 cell analyzer

1 hplc and up to 4 other analyzers (cell analyzer, biochemical analyzer etc.)



sample processing

duration
min

frequency
h-1

day-1

direct transfer

6'

10 h-1

240 day-1

sampling filtration

10'

6 h-1

144 day-1

sampling dilution

12'

5 h-1

120 day-1

sampling dilution filtration

15'

4 h-1

96 day-1



application
on-line analytics
the samples are automatically transferred to various directly coupled analytical devices. analysis is started trough re-mote control and results are collected from our software lucullus pims. cell-containing samples are passed to cell analyzers or flow cytometers. filtrated samples are directly injected in an hplc or transferred to enzymatic bio analyzers.
sample storage
samples are collected and stored in cooled conditions in the sample collector. the size of the sample collector can be adapted to specific needs based on different volumes, numbers and types of vials.it performs additional liquid handling steps, if needed. each vial is labeled with a unique barcode and sample id for distinctive identification in subsequent analytics.
sample processing
with the dilution module, biomass-containing samples are precisely diluted over a wide range. the simultaneous addition of reagents is used to perform protein precipitation, product extraction or staining reactions. the biomass-containing samples are filtrated with a unique filtration module with maximum sample yield. cross-contamination is prevented by using a new filter section for each sample. the variety of available filter membranes allows to meet specific requirements, regarding cell-densi
sampling
biomass-containing samples are drawn automatically from stainless steel and benchtop glass bioreactors maintaining their sterility. volumes up to 2 ml are drawn with minimum sample loss. using multiplexer modules, up to 16 bioreactors or downstream devices are coupled independently, each connected with a sample line of up to 10 m length. the sampling frequency lies between 6 and 15 minutes only, depending on sample processing steps.
information
  • applied articles
    automated bioreactor sampling ...
    2020-12-05
    no data available for the time being
relevant
  • lucullus pims
  • roche cedex hires analyzer
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marketing@alit.com.cn       hr@alit.com.cn

hotline:400-820-2919   office tel:021-62299622 after-sales telephone:021-62299622-8010

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